Abstract #0702

In vivo 7 Tesla probabilistic neuroimaging structural atlas of human pedunculotegmental, oral pontine reticular and paramedian-raphe nuclei

Marta Bianciardi¹, Christian Strong², Nicola Toschi^1,3, Brian Edlow⁴, Bruce Fischl¹, Emery N Brown⁵, Bruce R Rosen¹, and Lawrence L Wald¹

¹Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, ²Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States, ³Medical Physics Section, Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome “Tor Vergata”, Rome, Italy, ⁴Department of Neurology, A. A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, ⁵Department of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, United States

Mesopontine-tegmental nuclei such as the pedunculotegmental, oral-pontine-reticular and paramedian-raphe nuclei modulate arousal and motor functions. Dysfunction of these nuclei is implicated in the pathogenesis of disorders of consciousness, sleep disorders, and neurodegenerative diseases. However, a stereotaxic probabilistic atlas of these nuclei in humans does not exist. We used segmentation of 1.1 mm-isotropic 7 Tesla diffusion-fractional-anisotropy and T2-weighted images to generate and validate an in vivo probabilistic neuroimaging structural atlas of these nuclei in MNI space. We constructed this atlas to aid the localization of these nuclei in conventional images in future research and clinical studies of arousal and motor functions.

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