Meeting Banner
Abstract #0706

Optimization of acquisition and analysis methods for clinical dynamic susceptibility contrast (DSC) MRI using a validated digital reference object

Natenael B Semmineh1, Ashley M Stokes1, Laura C Bell1, Jerrold L Boxerman2, C Chad Quarles1, and Natenael B Semmineh3

1Translational Bioimaging, Barrow Neurological Institute, Phoenix, AZ, United States, 2Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States, 3imaging research, Barrow Neurological Institute, Phoenix, AZ, United States

Brain tumor DSC-MRI studies can be confounded by T1 and T2* effects that occur when the contrast agent extravasates. Traditionally a combination of contrast agent pre-loading and leakage correction techniques are used to minimize T1 leakage effects, but currently there is no consensus on the most robust dosing scheme. Using a validated DSC-MRI digital reference object we characterize the influence of pre-load dosing schemes, acquisition pulse parameters, and leakage correction methods on CBV accuracy. Our goal is to leverage this computational approach to identify the optimal combination of parameters for brain tumor CBV mapping.

This abstract and the presentation materials are available to members only; a login is required.

Join Here