Abstract #0738

Targeted Delivery of Stem Cells to the Brain using Real Time Interventional MRI

Miles E. Olsen¹, Scott C. Vermilyea^2,3, Jianfeng Lu⁴, Ethan K. Brodsky^1,5, Scott Guthrie², Yunlong Tao⁴, Eva M. Fekete⁶, Marissa K. Riedel⁶, Kevin Brunner², Carissa Boettcher², Viktorya Bondarenko², Andrew A. Alexander^1,2,4,6, Soo Chun Zhang^3,7, Marina E. Emborg^1,2,3, and Walter F. Block^1,8

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Preclinical Parkinson’s Research Program, University of Wisconsin - Madison, Madison, WI, United States, ³Neuroscience Training Program, University of Wisconsin - Madison, Madison, WI, United States, ⁴Waisman Center, University of Wisconsin - Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Psychiatry, University of Wisconsin - Madison, Madison, WI, United States, ⁷Neuroscience, University of Wisconsin - Madison, Madison, WI, United States, ⁸Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

We present an intraoperative MRI protocol for stereotaxic surgery to precisely deliver induced pluripotent stem cells to targeted locations within the brain of a non-human primate model.

Previously, these surgeries were performed in stereotaxic operating rooms with no intraoperative imaging, or in a conventional MRI system without real-time guidance. Those environments complicate the goals of ensuring precise cannula tip placement before injection, and being able to perform the desired number of injections during the anesthesia window. Our platform enables surgeons to quickly achieve precise tip placement, and confirm via imaging that cells were deposited at the intended target.

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