In this study we describe the analysis of a dataset including 178 subjects with and without Osteoarthritis using Topological data analysis (TDA), a machine-learning tool that involves projecting individual patients into the ‘syndromic space’ defined by all outcome variables simultaneously. Demographics, patient reported outcomes Kellgren-Lawrence grading, MRI WORMS morphological grading, cartilage relaxation times, gait kinematics and kinetics during walking were simultaneously considered to define the data topology. TDA shows the presence of subgroups characterized by a strong biochemical signature, showing how this new technique could be used to extract insight from complex data, allowing for more personalized characterization of each individual.
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