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Abstract #0785

Respiratory Phase-Matched MR-based Attenuation Correction (MRAC) for Four-Dimensional (4D) PET in PET/MRI: A Feasibility Study

Jaewon Yang1, Florian Wiesinger2, Anne Menini2, Jing Liu1, Thomas A. Hope1, Youngho Seo1, and Peder E. Z. Larson1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2GE Global Research

PET/MRI is capable of simultaneous respiratory motion-resolved four-dimensional (4D) PET/4D MRI data acquisitions. Therefore, it is important to develop a clinically applicable method for respiratory phase-matched MR-based attenuation correction (MRAC) for accurate 4D PET quantification. This study proposed 4D MRAC protocols modifying the current MRAC protocol and evaluated their performance using a patient with liver metastases. For qualitative analysis, 4D MRAC improved phase-mismatch at the lung/liver interface substantially. For quantitative analysis, 4D MRAC improved PET quantification by 10-30% increase of PET-avid tumor uptake values, compared to static MRAC, specifically for the tumors located at the lung/liver interface.

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