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Abstract #0802

Longitudinal Analysis of Vascular Inflammation and Intraluminal Thrombus Composition using High Resolution MRI in Abdominal Aortic Aneurysms

Chengcheng Zhu1, Bing Tian2, Joseph Leach1, David Saloner1, and Michael D Hope1

1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2Radiology, Changhai Hospital, Shanghai, People's Republic of China

Clinical management of abdominal aortic aneurysm (AAA) disease is based on the maximal diameter. Vascular inflammation and intraluminal thrombus (ILT) composition have been explored as novel imaging markers of progressive AAA disease, but studies to date have been limited by short follow-up time (~6 month). We followed 37 patients for an average of 4 years using CT/CTA and high resolution black-blood MRI. Our results show that inflammation identified by delayed ultrasmall superparamagnetic iron oxide (USPIO) particle uptake was strongly associated with AAA growth and/or intervention, whereas ILT composition was not. Imaging of vascular inflammation may improve AAA patient risk stratification.

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