Abstract #0804

In Vivo Magnetic Resonance Elastography of Abdominal Aortic Aneurysm in A Porcine Model

Huiming Dong MS^1,2, Matthew Joseph BS³, Prateek Kalra MS¹, Xiaokui Mo PhD⁴, Richard White MD^1,5, Rizwan Ahmad⁶, and Arunark Kolipaka PhD^1,2,5

¹Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ²Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ³Dorthy M. Davis Heart and Lung Research Institute Interventional Cardiology Cath Core Lab, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁴Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁵Department of Internal Medicine-Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ⁶Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States

Abdominal aortic aneurysm (AAA) can result in life-threatening aortic rupture. Although AAA diameter is utilized for assessing rupture risk clinically, it is a poor indicator of rupture potential. Aortic stiffness is an important biomechanical property that can provide critical information about the overall mechanical integrity of AAA and thus results in more accurate rupture risk evaluation.Therefore, the aim of this study is to utilize non-invasive in vivo MRE to estimate aortic stiffness in AAA-induced animal models, and compare it with the stiffness obtained from ex vivo mechanical testing as well as AAA diameters.

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