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Abstract #0812

Comparison of NODDI and WMTI microstructural parameters in typical development

Kirsten M. Lynch1, Farshid Sepehrband1, Arthur W. Toga1, and Kristi A. Clark1

1Laboratory of Neuro Imaging, University of Southern California, Los Angeles, CA, United States

Childhood and adolescence is an extended period of postnatal maturation characterized by dynamic changes in white matter microstructure. Multi-shell diffusion MRI (dMRI) models, such as neurite orientation dispersion and density imaging (NODDI) and white matter tract integrity (WMTI) provide an invaluable measure for the study of child development with tissue compartment estimates. NODDI and WMTI are based on similar frameworks, however they differ in several model assumptions. This study provides a comparison of NODDI and WMTI intra-axonal volume fraction model fittings in a cohort of children ages 0 -18 years in order to determine which model best reflects neurodevelopmental features.

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