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Abstract #0827

Functional lung MRI using matrix pencil decomposition and N2 multiple-breath washout measurements in cystic fibrosis

Grzegorz Bauman1,2, Sylvia Nyilas3,4, Orso Pusterla1,2, Tanja Haas1, Michael Ith5, Bernd Jung5, Carmen Casaulta3, Gregor Sommer6, Enno Stranzinger5, Urs Frey4, Philipp Latzin3,4, and Oliver Bieri1,2

1Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland, 4Department of Pediatric Pneumology, University Children's Hospital Basel (UKBB), Basel, Switzerland, 5University Institute for Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, Switzerland, 6Department of Radiology, University of Basel Hospital, Basel, Switzerland

This study examines a correlation between the functional lung MRI using matrix pencil decomposition and lung function tests in patients with cystic fibrosis. A strong correlation between the global ventilation inhomogeneity index (LCI) from multiple breath washout and ventilation/perfusion impairment in the lung determined by functional MRI is observed. The results of our study support the potential of functional MRI as a diagnostic tool in monitoring disease progression in cystic fibrosis.

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