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Abstract #0829

Assessment of cystic fibrosis disease using UTE imaging with XD-GRASP reconstruction: a comparison with CT

Jean Delacoste1, Catherine Beigelman1, Li Feng2, Jerome Yerly1,3, Davide Piccini1,4, Daniel K. Sodickson2, Ricardo Otazo2, Matthias Stuber1,3, and Alain Sauty5,6

1Department of Radiology, University Hospital (CHUV) and University of Lausanne (Unil), Lausanne, Switzerland, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, 5Adult CF multisites unit, Hospital of Morges, Morges, Switzerland, 6Service of Pneumology, Department of Medicine, University Hospital (CHUV), Lausanne, Switzerland

Motion resolved reconstructions, using compressed sensing, of 3D ultra short echo time (UTE) acquisitions in cystic fibrosis patients were performed. The definition of the lung-liver interface was quantified and found to be significantly higher than that in motion corrupted reconstructions of the whole datasets. The Helbich-Bhalla score for cystic fibrosis was determined using both computed tomography (CT) and MRI data. Correlation between scores obtained with both modalities was good (ρ=0.77) but consistency was moderate (ICC=0.62). This was due to average MRI scores being lower by 15%, most likely because mosaic perfusion could not be assessed with MRI.

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