Abstract #0829

Assessment of cystic fibrosis disease using UTE imaging with XD-GRASP reconstruction: a comparison with CT

Jean Delacoste¹, Catherine Beigelman¹, Li Feng², Jerome Yerly^1,3, Davide Piccini^1,4, Daniel K. Sodickson², Ricardo Otazo², Matthias Stuber^1,3, and Alain Sauty^5,6

¹Department of Radiology, University Hospital (CHUV) and University of Lausanne (Unil), Lausanne, Switzerland, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, ⁵Adult CF multisites unit, Hospital of Morges, Morges, Switzerland, ⁶Service of Pneumology, Department of Medicine, University Hospital (CHUV), Lausanne, Switzerland

Motion resolved reconstructions, using compressed sensing, of 3D ultra short echo time (UTE) acquisitions in cystic fibrosis patients were performed. The definition of the lung-liver interface was quantified and found to be significantly higher than that in motion corrupted reconstructions of the whole datasets. The Helbich-Bhalla score for cystic fibrosis was determined using both computed tomography (CT) and MRI data. Correlation between scores obtained with both modalities was good (ρ=0.77) but consistency was moderate (ICC=0.62). This was due to average MRI scores being lower by 15%, most likely because mosaic perfusion could not be assessed with MRI.

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