Abstract #0834

A new COPD phenotype characterized by hyperpolarized xenon-129 MRI

Kun Qing¹, Sahar Mansoor¹, John P. Mugler, III¹, Talissa A. Altes², Nicholas J. Tustison¹, Kai Ruppert³, Jaime F. Mata¹, G.Wilson Miller¹, Iulian C. Ruset⁴, F.William Hersman^4,5, Joanne M. Cassani², and Yun Michael Shim¹

¹University of Virginia, Charlottesville, VA, United States, ²University of Missouri School of Medicine, Columbia, MO, United States, ³University of Pennsylvania, Philadelphia, PA, United States, ⁴Xemed, LLC, Durham, NH, United States, ⁵University of New Hampshire, Durham, NH, United States

Existing literature describes two distinctive phenotypes of chronic obstructive pulmonary disease (COPD): airway-predominant chronic bronchitis and alveolar-predominant emphysema. In this study, based on results from pulmonary function tests and computed tomography, we found a new mixed phenotype of COPD. This mixed phenotype showed minimal emphysematous tissue destruction, but low diffusion lung capacity (DLCO). Subsequent hyperpolarized xenon-129 MRI results indicated that gas exchange to the pulmonary blood in lungs for this mixed phenotype was significantly impaired as compared to controls and the classic COPD phenotypes.

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