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Abstract #0834

A new COPD phenotype characterized by hyperpolarized xenon-129 MRI

Kun Qing1, Sahar Mansoor1, John P. Mugler, III1, Talissa A. Altes2, Nicholas J. Tustison1, Kai Ruppert3, Jaime F. Mata1, G.Wilson Miller1, Iulian C. Ruset4, F.William Hersman4,5, Joanne M. Cassani2, and Yun Michael Shim1

1University of Virginia, Charlottesville, VA, United States, 2University of Missouri School of Medicine, Columbia, MO, United States, 3University of Pennsylvania, Philadelphia, PA, United States, 4Xemed, LLC, Durham, NH, United States, 5University of New Hampshire, Durham, NH, United States

Existing literature describes two distinctive phenotypes of chronic obstructive pulmonary disease (COPD): airway-predominant chronic bronchitis and alveolar-predominant emphysema. In this study, based on results from pulmonary function tests and computed tomography, we found a new mixed phenotype of COPD. This mixed phenotype showed minimal emphysematous tissue destruction, but low diffusion lung capacity (DLCO). Subsequent hyperpolarized xenon-129 MRI results indicated that gas exchange to the pulmonary blood in lungs for this mixed phenotype was significantly impaired as compared to controls and the classic COPD phenotypes.

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