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Abstract #0844

Sleep deprivation affects white matter integrity in cognitively vulnerable individuals

Hengyi Rao1, Sihua Xu1, Zhuo Fang1, Fan Yang1, Andrea Spaeth1, Namni Goel1, Mathias Basner1, Sumei Wang1, David F. Dinges1, and John A. Detre1

1University of Pennsylvania, Philadelphia, PA, United States

Using DTI, we examined the effects of one night of acute total sleep deprivation on fractional anisotropy (FA), an index reflecting the degree of anisotropic water diffusion in brain white matter. Sleep deprivation significantly increases FA in the right superior longitudinal fasciculus (SLF) in individuals who were cognitively vulnerable to sleep loss, while no FA changes were observed in cognitively resistant individuals. Vulnerable subjects also showed lower FA in the right SLF than resistant subjects at baseline before sleep loss, suggesting both trait- and state-dependent interactions between SLF microstructure and cognitive vulnerability to sleep deprivation.

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