Meeting Banner
Abstract #0847

Feasibility of bone mineral and water quantification in vivo by solid-state 31P and 1H MRI at 3T

Xia Zhao1, Hee Kwon Song1, Alan C. Seifert1, Cheng Li1, and Felix W. Wehrli1

1University of Pennsylvania, Philadelphia, PA, United States

Surrogates for bone matrix density, pore volume fraction and mineral density can be studied with solid-state MRI. Here, we developed an in vivo MRI protocol to simultaneously quantify bone mineral 31P and bound and pore water on a 3 Tesla clinical MRI system with a dual-frequency extremity coil and 3D 1H UTE and 31P PETRA-ZTE pulse sequences. Measurements in the mid-tibia of 10 subjects yielded 7.06±1.53mol/L 31P, and 13.99±1.26 and 10.39±0.80mol/L H2O for total and bound water, respectively, in good agreement with prior ex vivo data. The work suggests that both organic and inorganic phases of cortical bone can be quantitatively evaluated in vivo with a single, integrated protocol.

This abstract and the presentation materials are available to members only; a login is required.

Join Here