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Abstract #0864

Intravoxel incoherent motion MR imaging for staging liver fibrosis and monitoring anti-fibrotic response to losartan: an experimental study in rat model

Caiyuan Zhang1, Yong Zhang2, and Dengbin Wang1

1Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, 2MR Research China, GE Healthcare, Shanghai, China, Shanghai, People's Republic of China

To evaluate the feasibility of intravoxel incoherent motion (IVIM) MR imaging to stage liver fibrosis and its capability for monitoring anti-fibrotic response to treatment, we performed IVIM MR imaging for rats model induced by carbon tetrachloride and for rats treated with losartan. Our studies demonstrated that D* is helpful to stage early and moderate fibrosis, and f is beneficial to discriminate advanced liver fibrosis and cirrhosis. In losartan treated rats, D* and f showed statistical significance compared with CCl4 alone. We concluded that perfusion parameters derived from IVIM have potential to monitor fibrosis progression and evaluate anti-fibrosis response to treatment.

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