To evaluate the feasibility of intravoxel incoherent motion (IVIM) MR imaging to stage liver fibrosis and its capability for monitoring anti-fibrotic response to treatment, we performed IVIM MR imaging for rats model induced by carbon tetrachloride and for rats treated with losartan. Our studies demonstrated that D* is helpful to stage early and moderate fibrosis, and f is beneficial to discriminate advanced liver fibrosis and cirrhosis. In losartan treated rats, D* and f showed statistical significance compared with CCl4 alone. We concluded that perfusion parameters derived from IVIM have potential to monitor fibrosis progression and evaluate anti-fibrosis response to treatment.
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