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Abstract #0866

An assessment of Intravoxel Incoherent Motion (IVIM) imaging in Detection of Acute Kidney Injury in Rodents

Keisuke Ishimatsu1, Shanrong Zhang1, Koji Sagiyama1, Ming Chang Hu2, Orson W Moe2, and Masaya Takahashi1

1Advanced Imaging Researh Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Internal Medicine / Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, UT Southwestern Medical Center, Dallas, TX, United States

The objective is to investigate the concept of intravoxel incoherent motion (IVIM) for diffusion weight imaging (DWI) in the kidney. We first compared the variability of three methods for bi-exponential fitting applied to the five data sets of DWI obtained in a mouse kidney. Subsequently these three methods were compared with an arterial spin labeling (ASL) in detection of acute kidney injury (AKI) in a rat model. The IVIM imaging did not detect any changes in the AKI model although the ASL clearly demonstrated the reduction of the perfusion.

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