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Abstract #0876

Comparison of in-vivo Lung Morphometry Models from 3D Multiple b-value 3He Diffusion-Weighted MRI

Ho-Fung Chan1, Juan Parra-Robles1,2, Guilhem J Collier1, and Jim M Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Department of Bioengeering, Universidad Carlos III de Madrid, Madrid, Spain

The cylinder (CM) and stretched exponential (SEM) models have been proposed as a means of estimating lung alveolar microstructural length scales (L­m for CM and LmD for SEM) from multiple b-value hyperpolarised gas DW-MRI. This work compares Lm and LmD in healthy normals, idiopathic pulmonary fibrosis, and COPD patients. A correlation with a non-linear trend was observed between the Lm and LmD parameters. This suggests that the two models have different operational ranges of length scale estimation accuracy due to inherent differences in their geometrical and mathematical assumptions.

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