Abstract #0881

Cervical spinal cord and brain MRS alterations in normal appearing white matter of multiple sclerosis (MS) patients at 3T

Patrik Oliver Wyss^1,2,3,4, Anke Henning^1,2,5, Andreas Hock^1,6, Andreas Lutterotti⁷, Roland Martin⁷, and Spyros Kollias⁴

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ³Swiss Paraplegic Centre, Nottwil, Switzerland, ⁴Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, ⁵Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, ⁶Department of Psychiatry, Psychotherapy and Psychosomatics Hospital of Psychiatry, University of Zurich, Zurich, Switzerland, ⁷Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital and University Zurich, Zurich, Switzerland

This investigation explores alterations of both cervical spinal cord and brain metabolite levels in normal appearing tissue in patients suffering from multiple sclerosis (MS). In the brain, a 2 dimensional J-resolved spectroscopy sequence and 2D prior-knowledge fitting is used and the metabolite cycling technique is applied to the cervical spinal cord at 3T. Relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients are included and alterations between brain and spinal cord metabolites are addressed.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.