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Abstract #0884

Acetate metabolism towards fatty acids is down-regulated in IDH1 mutant glioma as shown by 13C MRS

ChloƩ Najac1, Marina Radoul1, Pavithra Viswanath1, Myriam M Chaumeil1, and Sabrina M Ronen1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

IDH1 is the most prevalent driver mutation in lower-grade glioma and upgraded glioblastoma and is associated with additional metabolic reprogramming. Here, we investigated fatty acid biosynthesis and the role of acetate, which was recently recognized as a major fuel in primary glioblastoma. Labeling cells harboring either wild-type or mutant IDH1 with [1,2-13C]-acetate, we found a decrease in flux towards fatty acids in mutant IDH1 cells although the total fatty acid pools remained unchanged. Associated with cell biological assays, these results point to alternate sources for maintenance of fatty acid levels in IDH1 mutant cells.

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