IDH1 is the most prevalent driver mutation in lower-grade glioma and upgraded glioblastoma and is associated with additional metabolic reprogramming. Here, we investigated fatty acid biosynthesis and the role of acetate, which was recently recognized as a major fuel in primary glioblastoma. Labeling cells harboring either wild-type or mutant IDH1 with [1,2-13C]-acetate, we found a decrease in flux towards fatty acids in mutant IDH1 cells although the total fatty acid pools remained unchanged. Associated with cell biological assays, these results point to alternate sources for maintenance of fatty acid levels in IDH1 mutant cells.
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