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Abstract #0901

Altered Functional Network Topology in Children with Complex Congenital Heart Disease is Associated with Reduced Regional Cerebral Perfusion and Cognitive Outcomes

Vincent Schmithorst1, Vince Lee1, Cecilia Lo2, and Ashok Panigrahy1

1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 2University of Pittsburgh

Pseudo-continuous ASL (pCASL) and resting-state BOLD data was obtained from a cohort of pre-adolescent patients with complex congenital heart disease (CHD) and healthy controls. CHD patients displayed altered functional network topology (network segregation) in posterior default mode, subcortical, and prefrontal regions, as well as decreased regional CBF in subcortical and anterior default mode regions. These alterations in functional topology and regional CBF were also associated with deficits in cognitive performance as measured by the NIH Toolbox (crystallized cognition). These results suggest regional alterations in neuronal-vascular coupling may underlie neurocognitive deficits in pre-adolescent CHD patients.

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