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Abstract #0911

Does T1 Mapping Provide Additional Information in the Context of Hepatic Iron Overload?

Aaryani Tipirneni-Sajja1, Eric M. Kercher1, Ralf B. Loeffler1, Ruitian Song1, Matthew D. Robson2, M. Beth McCarville1, Jane S. Hankins3, and Claudia M. Hillenbrand1

1Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Hematology, St. Jude Children's Research Hospital, Memphis, TN, United States

Hepatic iron content (HIC) is linearly correlated with R2*. Currently, there is little data on in vivo human liver iron assessment via longitudinal relaxation T1 (or R1) although an animal study previously suggested linear association, too. This study investigates hepatic T1 quantification in a breathhold by using ShMOLLI. T1 and T2* liver mapping were performed in 124 iron loaded patients. We found linear association between R1 and R2*/HIC values for mild-moderate HIC at 1.5T and 3T. No association between T1 and T2* was found for high HIC, which is most likely due to technical limits of ShMOLLI for short T2*.

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