Abstract #0915

Ventral and dorsal horn grey matter neurodegeneration remote from stenosis in cervical spondylotic myelopathy

Patrick Grabher¹, Siawoosh Mohammadi², Gergely David¹, and Patrick Freund^1,3,4,5

¹Spinal Cord Injury Center, University of Zurich, Zurich, Switzerland, ²Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Department of Neurophysics, Max Planck Insitute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, ⁵Department of Brain Repair and rehabilitation, UCL Institute of Neurology, London, United Kingdom

Cervical spondylotic myelopathy (CSM) is the most frequent spinal cord disorder. Next to focal degeneration at the compression site, the rostral cervical white and grey matter undergo atrophic changes, the magnitude relating to clinical impairment. In this study, we assess above stenosis regional grey matter changes and demonstrate that next to bilateral dorsal horn atrophy, the normal appearing ventral horns show diffusivity changes which relate to white matter integrity loss.

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