Abstract #0927

In Vivo Assessment of Cardiomyocyte Performance Using Combined Cardiac DENSE and cDTI

Patrick Magrath^1,2, Luigi E. Perotti ^1,2, Eric Aliotta ^2,3, Ilya A. Verzhbinsky ², Kévin Moulin², and Daniel B. Ennis^1,2,3

¹Department of Bioengineering, University of California, Los Angeles, CA, United States, ²Department of Radiological Sciences, University of California, Los Angeles, CA, United States, ³Biomedical Physics IDP, University of California, Los Angeles, CA, United States

Circumferential strain (E_cc) derived from cardiac DENSE 3D displacement maps is a promising biomarker for diagnosing early stages of cardiac disease. E_cc is commonly evaluated only in the mid-wall where it is expected to align with the local myofiber direction. Our aim was to combine cDTI and DENSE displacement data to directly characterize strain along the fiber direction (E_ff) throughout the heart. Across all healthy subjects (N=9), E_ff had a smaller peak systolic transmural gradient than E_cc (-0.035±0.041 vs. -0.097±0.030 (unitless), p<0.001). E_ff is a more spatially uniform measure of regional LV function in healthy volunteers and provides a microstructurally anchored measure of cardiomyocyte performance.

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