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Abstract #0942

Saturated fatty acid fraction in breast adipose tissue is higher in patients with cancer than in those with benign lesions

Sungheon Gene Kim1, Neeti Bagadiya1, Pippa Storey1, Melanie Moccaldi1, and Linda Moy1

1Center for Advanced Imaging Innovation and Research, Radiology, New York University School of Medicine, New York, NY, United States

Gradient-echo Spectroscopic Imaging (GSI) was used to conduct voxel-wise analysis of fatty acid composition in breast adipose tissue in postmenopausal women. Parametric maps of fatty acid fractions show significantly higher saturated fatty acids in women with malignant tumors than in those with benign lesions. This result is consistent with a previous study based on manually selected regions of interest, and suggests that, for post-menopausal women, higher saturated fatty acids may be related to breast cancer development. Non-invasive evaluation of lipid composition using GSI may aid in breast cancer risk assessment and provide insight into physiological mechanisms that facilitate cancer development.

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