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Abstract #0961

Dynamic resting state fMRI in mice: detection of Quasi-Periodic Patterns

Michaƫl Belloy1, Maarten Naeyaert1, Georgios Keliris1, Anzar Abbas2, Shella Keilholz2, Annemie Van Der Linden1, and Marleen Verhoye1

1Bio-Imaging Lab, Antwerpen, Belgium, 2MIND lab, Atlanta, GA

We report, to our knowledge, the first application of a dynamic rsfMRI approach in mice and show the reliable detection of Quasi-Periodic Patterns (QPP) at both the group-level as well as in single-subject data. These patterns are consistent with QPPs detected previously in humans and rats, displaying a high intensity wave spreading across the cortex from lateral towards upward medial, followed by a low intensity wave in the same direction. These findings are promising for the application of QPPs towards investigating mouse resting state functional connectivity and its development as a potential new pre-clinical tool.

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