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Abstract #0989

MR Elastography and Perfusion MRI for the Early Assessment of Treatment Response in Soft Tissue Sarcomas

Kay Pepin1, Roger Grimm2, Soudabeh Kargar3, Sarah James1, Matthew Howe2, Karen Fritchie4, Matthew Frick2, Doris Wenger2, Richard Ehman2, Nadia Laack1, Michael Herman1, and Deanna Pafundi1

1Radiation Oncology, Mayo Clinic, Rochester, MN, United States, 2Radiology, Mayo Clinic, Rochester, MN, United States, 3Mayo Graduate School, Mayo Clinic, Rochester, MN, United States, 4Pathology, Mayo Clinic, Rochester, MN, United States

Advanced imaging is a critical component in the development of patient-specific and novel treatment strategies, and the non-invasive evaluation of early response in sarcomas. Our central hypothesis is that changes in sarcoma stiffness quantified with MRE and perfusion with DCE-MRI throughout therapy can predict response. Soft tissue sarcomas are a rare malignancy arising in a wide range of anatomic locations. Anatomy-specific imaging protocols were developed to evaluate soft tissue sarcomas in 9 patients. In 3 patients, we investigated the feasibility to assess response to radiation therapy and observed a decrease in parameters related to tumor stiffness and perfusion metrics.

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