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Abstract #0995

Spin-lock imaging of exogenous exchange-based contrast agents to assess tissue pH

Zhongliang Zu1, Hua Li1, Xiaoyu Jiang1, and John C Gore1

1Vanderbilt University, Nashville, TN, United States

We measured spin-lock relaxation rates as a function of locking field to quantify tissue pH and the concentration of an exogenous X-ray contrast agent, iohexol, based on chemical exchange effects. Results show that spin-lock imaging can be used to detect exchange-based agents and the effects of tissue acidification.

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