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Abstract #1002

In vivo whole-blood $$$T_2$$$ versus $$$HbO_2$$$ calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion

Michael C Langham1, Ana E Rodríguez-Soto1, Nadav Schwartz2, and Felix W Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, United States

The relationship between whole-blood T2 and blood hemoglobin oxygen saturation (HbO2) can be modeled as $$${1\over T_{2b}}={1\over T_{2o}}+K(1-HbO_2)^2$$$, where K and T2o are determined empirically in vitro. The feasibility of estimating K and T2o in vivo is investigated with T2-prepared bSSFP at 1.5T in the superficial femoral vein (SFV) with intermittent cuff occlusion. In this manner a range of HbO2 were achieved allowing quantification of venous oxygen saturation via MR susceptometry, a method that had been validated rigorously against blood gas analysis. Initial result (K=19.6Hz, T2o=185ms) is lower than the literature value (24.6Hz, 254ms) but not unexpected because transient bSSFP signal is acquired while disturbing the T2-prepared magnetization.

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