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Abstract #1004

Early Cancer Detection Using Paramagnetic Liposome by a Novel Contrast Mechanism with Active-feedback Magnetic Resonance Imaging

Sayoni Ray1, Chao-Hsiung Hsu2, Zhao Li1, Fang-Chu Lin1, Ying-Chih Lin2, and Yung-Ya Lin1

1DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY, University Of California, Los Angeles, Los Angeles, CA, United States, 2Department of Chemistry, National Taiwan University, Taiwan

The detection of early tumors requires creating the contrast between healthy and tumor tissues that share a common morphology, making it difficult to distinguish them by relaxation-based MRI technique. Here we have exploited the small magnetic differences between the healthy and tumor tissues to develop a detection technique of early tumors using theranostic nanoparticle paramagnetic (Gd) liposome along with continuous wave (CW) irradiation in the presence of the feedback magnetic field from an active-feedback electronic device for in vivo subcutaneous glioblastoma multiforme mouse models and obtained significantly superior contrast compared to the conventional MRI technique, in agreement with spin-dynamics simulations.

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