Abstract #1004

Early Cancer Detection Using Paramagnetic Liposome by a Novel Contrast Mechanism with Active-feedback Magnetic Resonance Imaging

Sayoni Ray¹, Chao-Hsiung Hsu², Zhao Li¹, Fang-Chu Lin¹, Ying-Chih Lin², and Yung-Ya Lin¹

¹DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY, University Of California, Los Angeles, Los Angeles, CA, United States, ²Department of Chemistry, National Taiwan University, Taiwan

The detection of early tumors requires creating the contrast between healthy and tumor tissues that share a common morphology, making it difficult to distinguish them by relaxation-based MRI technique. Here we have exploited the small magnetic differences between the healthy and tumor tissues to develop a detection technique of early tumors using theranostic nanoparticle paramagnetic (Gd) liposome along with continuous wave (CW) irradiation in the presence of the feedback magnetic field from an active-feedback electronic device for in vivo subcutaneous glioblastoma multiforme mouse models and obtained significantly superior contrast compared to the conventional MRI technique, in agreement with spin-dynamics simulations.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.