Abstract #1008

Sparse Prostate Cancers on Whole-Mount Histopathology and Multiparametric MRI

Olga Starobinets^1,2, Jeffry P Simko³, Kyle Kuchinsky³, Peter R Carroll⁴, Kirsten L Greene⁴, John Kurhanewicz^1,2, and Susan M Noworolski^1,2

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, San Francisco, CA, United States, ³Department of Pathology, University of California, San Francisco, San Francisco, CA, United States, ⁴Department of Urology, University of California, San Francisco, San Francisco, CA, United States

The study purpose was to establish incidence and Gleason Score of sparse lesions on whole-mount histopathology in post-prostatectomy samples and to identify imaging characteristics associated with sparse cancers detected on multiparametric MRI (mpMRI). Based on histopathology, sparse lesions were smaller than dense lesions (0.065cc vs 0.916cc), with the majority (56/57 sparse) being low-grade (GS3+3). On imaging, we found statistically significant differences between sparse GS3+3 and benign tissues on apparent diffusion coefficient and peak enhancement maps. This combined with small-size and low-grade, and thus low clinical importance [1] of sparse lesions suggests that current mpMRI capabilities are sufficient to characterize these lesions.

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