The hippocampus, including the dentate gyrus (DG), and the sensory cortices, which consist of six distinct layers, have reciprocal connections with the entorhinal cortex (EC). However, the low frequency hippocampal-cortical interactions and layer-specific cortical responses remains largely unknown. Combining the optogenetic stimulation and manganese-enhanced MRI, the present study revealed layer-specific responses of sensory cortices and EC involvement in hippocampal-cortical interactions during low frequency stimulation, but not high frequency, at dorsal DG. In summary, we demonstrated an effective combination of optogenetic stimulation and manganese-enhanced MRI to uncover the frequency-dependent and cortical layer-specific responses involved in brain-wide interactions.
This abstract and the presentation materials are available to members only; a login is required.