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Abstract #1067

Evaluation of the Vascular Perfusion in Activated Brown Adipose Tissue by Dynamic Contrast Enhanced MR Imaging

Jadegoud Yaligar1, Sanjay Kumar Verma 1, Venkatesh Gopalan 1, Anantharaj Rengaraj1, Tian Xianfeng1, and S. Sendhil Velan 1

1Laboratory of Metabolic Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore

Vasculature plays an important role in white and brown adipose tissue (WAT and BAT) metabolism. In expanding WAT, abnormal vasculature may lead to energy (fat) deposition whereas in activated BAT it may potentially facilitate the energy consumption by oxidizing the fat. Understanding the vascular network and blood perfusion properties of the activated BAT is important for triglyceride clearance, increased blood flow and oxygen. In this feasibility study we have investigated the vascular properties and blood perfusion rate constant of the activated BAT by quantitative dynamic contrast enhanced MR imaging in a rodent model.

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