We propose a novel, efficient diffusion method, called isotropic diffusion weighted MRI (IDWI), for measuring orientationally-averaged properties of tissue water diffusion, free from modulations due to anisotropy. Using efficient diffusion gradient sampling schemes, IDWI rapidly and accurately quantifies the mean apparent diffusion coefficient (mADC) over a wide range of b-values, along with other important rotation-invariant intrinsic microstructural parameters, such as the mean t-kurtosis. The ability to efficiently and effectively remove modulations due to anisotropy in images with high-b values may improve existing diffusion MRI techniques and spur the development and clinical translation of new methods with improved biological specificity.
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