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Abstract #1101

Towards opto-fMRS:  Ultra high field MRS measurement of T2* changes due to optogenetic stimulation

Jamie Near1,2, Dan Madularu1,2, Jennifer Robinson3, Chathura Kumaragamage4, Axel Mathieu2, Sylvain Williams1,2, M Natasha Rajah1,2, and Uzay Emir5

1Department of Psychiatry, McGill University, Montreal, QC, Canada, 2Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, 3Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada, 4Biomedical Engineering, McGill University, Montreal, QC, Canada, 5Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Combining optogenetics with fMRI/fMRS (opto-fMRI/opto-fMRS) offers the unique potential to study the whole brain functional or neurochemical effects of stimulating specific neuronal populations within a given brain region. In this study, we investigated the BOLD functional changes and neurochemical changes resulting from optogenetic stimulation of glutamatergic or GABAergic neurons in the medial septum. Stimulation of both glutamatergic and GABAergic neurons in the medial septum resulted in prominent bold activation within the hippocampus, and in other regions. This study represents a unique imaging investigation into the functional response to stimulation of multiple distinct neuronal populations within a single brain region.

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Abstract