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Abstract #1105

Qualitative and quantitative analysis of amide proton transfer-weighted MR images at 3 Tesla of adult gliomas

Xianlong Wang1, Hao Yu2, Shanshan Jiang2, Yu Wang3, Yanyu Wang2, Ge Zhang4, Chunxiu Jiang2, Guodong Song5, Yi Zhang6, Hye-Young Heo6, Jinyuan Zhou6, and Zhibo Wen2

1Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, People's Republic of China, 2Radiology, Zhujiang Hospital of Southern Medical University, 3Pathology, Zhujiang Hospital of Southern Medical University, 4Radiology, Hainan General Hospital, 5Radiology, Beijing Hospital, 6Radiology, Johns Hopkins University

We evaluated the reliability and clinical value of amide proton transfer-weighted (APTW) MR imaging at 3 Tesla in adult gliomas. Fifty-seven patients with primary gliomas were recruited and scanned. Two radiologists evaluated the location and size of the APTW hyperintensity and enhancing areas, and measured the tumor and contralateral normal-appearing white matter (CNAWM) APTW values. The correlation between relative APTW (rAPTW) values and pathologic grades was calculated. Results showed APTW analysis had good reliability. APTW images almost showed the same compared with T1-weighted contrast-enhancing (T1W+C) images. The tumor rAPTW values had a strong positive correlation with pathologic grades.

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