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Abstract #1111

Asynchronous Local Analysis of simultaneous BOLD ASL Multislice Acquisition (ALABAMA): Toward Whole-Brain Noninvasive Estimation of Resting-State Neuronal-Vascular Coupling

Vincent Schmithorst1, Vince Lee1, and Ashok Panigrahy1

1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States

A method (ALABAMA) for regional estimation of the coupling between R2* fluctuations and log signal intensity (S0) (related to R2*-CBF coupling via a calibration factor) during the resting state is proposed. The method incorporates pseudo-continuous ASL (pCASL) labeling together with simultaneous multi-slice (SMS) and double-echo EPI acquisition for fast temporal resolution. The sequence yields robust positive ΔR2*-Δln S0 correlations in most resting-state networks, which may then be used to estimate resting-state neuronal-vascular coupling (NVC) with an additional calibration scan. However, negative correlations were found in posterior DMN and central executive network (CEN) regions, possibly reflective of altered flow-metabolism relationships.

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