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Abstract #1115

Hyperpolarized 13C Dynamic Breath-held Molecular Imaging to Detect Targeted Therapy Response in Patients with Liver Metastases

Zihan Zhu1,2, Irene Marco-Rius3, Michael A Ohliger1, Lucas Carvajal1, Jeremy W Gordon1, Hsin-Yu Chen1,2, Ilwoo Park1, Peng Cao1, Peter J Shin1, Eugene Milshteyn1,2, Cornelius von Morze1, Marcus Ferrone4, James B Slater1, Zhen Wang1, Peder E.Z. Larson1, Rahul Aggarwal5, Robert Bok1, John Kurhanewicz1, Pamela Munster5, and Daniel B Vigneron1

1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley and UCSF, San Francisco, CA, United States, 3University of Cambridge, United Kingdom, 4Department of Clinical Pharmacy, UCSF, San Francisco, CA, United States, 5Department of Medicine, UCSF, San Francisco, CA, United States

New clinical trials are using hyperpolarized 13C molecular imaging technology to evaluate tumor metabolic activity and response to targeted drug therapies. The goal of this work was to develop and apply an experimental setup for HP 13C MR investigations of cancer metastases to liver. In this study, patients with liver metastases were imaged and the results demonstrated sufficient SNR and data quality for the quantification of the localized conversion rate of [1-13C]pyruvate to [1-13C]lactate through lactate dehydrogenase (LDH), which is a pathway targeted by numerous emerging pharmaceutical agents and currently prescribed Everolimus.

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