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Abstract #1127

Panning for Salt: One Millimeter Resolution In Vivo Sodium MRI of the Human Eye at 7.0 Tesla Using a Six Channel Transceiver Array

Daniel Wenz1, Oliver Weinberger1, Andre Kuehne2, Helmar Waiczies2, Armin Nagel3,4, Celal Oezerdem1, Till Huelnhagen1, Darius Lysiak2, Lukas Winter1, Oliver Stachs5, Soenke Langner6, Erdmann Seeliger7, Bert Flemming7, and Thoralf Niendorf1,8

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, 2MRI.TOOLS GmbH, Berlin, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany, 5Department of Ophthalmology, University of Rostock, Rostock, Germany, 6Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany, 7Institute for Physiology, Charité University Medicine, Berlin, Germany, 8Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Sodium quantification in the eye may be a valuable aid not only in diagnosis of ocular diseases, but in follow-up after proton therapy of eye tumors. Recognizing this potential, this is the first report on high fidelity in vivo sodium (23Na) MRI of the human eye at 7.0 Tesla. To achieve this goal a six-channel 23Na transceiver array was designed, simulated, built and validated in phantoms. The in vivo studies demonstrated the feasibility of 1 mm isotropic spatial resolution 23Na MRI of the eye and provided encouragement for clinical studies.

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