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Abstract #1153

Combined fMRI-MRS measures simultaneous glutamate and BOLD-fMRI signals in the human brain at 7T

Betina Ip1,2, Adam Berrington2, Aaron T Hess3, Andrew Parker1, Holly Bridge2, and Uzay E Emir2

1Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 2Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom, 3Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom

We quantified neural activity using a novel method for simultaneous acquisition of blood-oxygenationlevel dependent (BOLD)-fMRI signals and proton magnetic resonance spectroscopy (1H -MRS)-MRI at 7 Tesla. We have demonstrated the correlation of glutamate, the principal excitatory neurotransmitter in the nervous system, with BOLD-fMRI responses during brief (64 s) periods of visual stimulation. These results establish the feasibility of concurrent measurements of BOLD-fMRI and neurochemicals at a temporal resolution compatible with human fMRI studies.

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