Abstract #1153

Combined fMRI-MRS measures simultaneous glutamate and BOLD-fMRI signals in the human brain at 7T

Betina Ip^1,2, Adam Berrington², Aaron T Hess³, Andrew Parker¹, Holly Bridge², and Uzay E Emir²

¹Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, ²Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom, ³Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom

We quantified neural activity using a novel method for simultaneous acquisition of blood-oxygenationlevel dependent (BOLD)-fMRI signals and proton magnetic resonance spectroscopy (¹H -MRS)-MRI at 7 Tesla. We have demonstrated the correlation of glutamate, the principal excitatory neurotransmitter in the nervous system, with BOLD-fMRI responses during brief (64 s) periods of visual stimulation. These results establish the feasibility of concurrent measurements of BOLD-fMRI and neurochemicals at a temporal resolution compatible with human fMRI studies.

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