In this study, we show that chemogenetic fMRI and 18 F FDG PET can sensitively dissect the functional neurocircuits of noradrenergic cells derived from rhombomere 4 expressing Hoxb1 during neurodevelopment. To address this, we used a novel genetically engineered mouse line expressing Designer Receptors Exclusively Activated for Designer Drugs (DREADD) in Hoxb1-derived noradrenargic neurons in several subpopulations throughout the pons and medulla. For the first time, we used ICA-based fMRI analaysis to dissect the complex polysynaptic pathways associated with chemogenetic modulation of Hoxb-1 derived noradrenargic neurons.
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