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Abstract #1161

Assessing the repeatability of absolute CMRO2 measurements from calibrated fMRI

Alberto Merola1, Michael A Germuska1, Kevin Murphy1, and Richard G Wise1

1CUBRIC, Cardiff University, Cardiff, United Kingdom

O2 metabolism is a crucial biomarker of brain physiology. We aim at measuring the repeatability of estimates of O2 metabolism obtained with a dual calibrated fMRI experiment and a newly proposed parameter estimation approach based on a forward model. The analysis is carried out on two datasets from volunteers scanned at rest. The performances are shown to depend on the physiological parameter considered, resolution (bulk or voxel-wise level) and decreasing from within- to between-sessions repeatability. Overall the repeatability is demonstrated to be comparable with PET and a previous calibrated fMRI method, but supplying a more complete mapping of brain O2 metabolism.

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