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Abstract #1173

MR guided High Intensity Focused Ultrasound for treating painful bone metastases: relating intra-procedural ADC changes and thermal dose to volume of ablated tissue

Sharon L Giles1,2, Matthew RD Brown3, Jessica Winfield1,2, David J Collins1, Ian Rivens4, John Civale4, Gail R ter Haar4, and Nandita M deSouza1

1CRUK Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom, 2CRUK Cancer Imaging Centre, Royal Marsden Hospital, London, United Kingdom, 3Pain Management Team, Department of Anaesthetics, Royal Marsden Hospital, 4Therapeutic Ultrasound, Institute of Cancer Research, London, United Kingdom

Thermal dose estimates and apparent diffusion coefficient (ADC) changes during MR-guided High Intensity Focused Ultrasound of painful bone metastases (n=11) were correlated with ablated tissue volumes assessed on Gd-T1W imaging acquired immediately, and at 30 days post-treatment. Thermal dose volume and mean maximum temperature were estimated from proton resonance frequency shift thermometry. Ablated tissue volume did not change significantly over 30 days. Mean maximum temperature and thermal dose volume were significant indicators of ablated volume, and mean maximum temperature was significantly higher in those with enduring ADC changes at Day 30. Further work will relate imaging changes to pain outcomes.

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