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Abstract #1175

Ultrashort Echo-Time Imaging based Skull Density Ratio Assessment for Transcranial MR guided Focused Ultrasound

Sijia Guo1, Jiachen Zhuo1, and Rao Gullapalli1

1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Transcranial MRI-guided focused ultrasound (tcMRgFUS) applications have been growing steadily on treatment of brain diseases. Typically a CT skull scan is used with the MR scan to perform treatment planning in tcMRgFUS procedures. In this study we examine the use of ultrashort echo time imaging to perform the skull imaging and assess the feasibility of using the information from MRI to perform treatment planning through acoustic and temperature modeling with skull characteristics generated from UTE imaging. We further compared the simulation results with existing data from tcMRgFUS treatment of essential tremor procedure that used CT images of the skull for treatment planning. We demonstrated that UTE based treatment planning is feasible and avoids the use of CT based images thus avoiding unnecessary radiation exposure.

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