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Abstract #1190

Pulmonary MRI Ventilation Defects in Asthma: Stochastic or Deterministic?

Rachel L Eddy1, Dante PI Capaldi1, Khadija Sheikh1, Sarah Svenningsen1, David G McCormack2, and Grace Parraga1

1Robarts Research Institute, London, ON, Canada, 2Division of Respirology, The University of Western Ontario, London, ON, Canada

Pulmonary MRI provides strong evidence of ventilation abnormalities that are temporally and spatially persistent; this has generated a paradigm shift in our understanding of asthma as a spatially and temporally heterogeneous, non-stochastic disease. Based on these findings, here our objective was to develop image-processing methods to estimate and mathematically describe the spatial probability distribution of MRI-derived ventilation defects. To accomplish this, we generated functional lung MRI atlases based on asthmatics who were evaluated before and post-methacholine using hyperpolarized 3He static-ventilation MRI. This proof-of-concept evaluation showed that in asthmatics, ventilation abnormalities are not diffuse nor stochastic, but heterogeneous and deterministic.

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