Abstract #1208

Correlations of beta-Amyloid and brain iron load (QSM): preliminary results of simultaneous assessment in a large sample

Jiri MG van Bergen¹, Xu Li², Frances-Catherine Quevenco¹, Sandra Leh¹, Anton F Gietl¹, Valerie Treyer^1,3, Rafeal Meyer¹, Alfred Buck³, Roger M Nitsch¹, Peter CM van Zijl², Christoph Hock¹, and Paul G Unschuld¹

¹Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland, ²F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, MD, United States, ³Department of Nuclear Medicine, University of Zurich, Switzerland

To extend findings on the use of QSM in Alzheimer’s Disease and possible direct interactions with Amyloid-β, this study is investigating a growing sample of elderly subjects using simultaneous assessment of Amyloid-PET for Aβ-load and QSM for estimation of iron load (indicated by susceptibility) using a combined PET-MRI instrument.

Our preliminary data suggests a significant correlation between susceptibility and Aβ in subjects with high brain Aβ load or clinically diagnosed Mild Cognitive Impairment, in several cortical and sub-cortical regions. The sample is expected to grow considerably in the upcoming months.

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