Meeting Banner
Abstract #1208

Correlations of beta-Amyloid and brain iron load (QSM): preliminary results of simultaneous assessment in a large sample

Jiri MG van Bergen1, Xu Li2, Frances-Catherine Quevenco1, Sandra Leh1, Anton F Gietl1, Valerie Treyer1,3, Rafeal Meyer1, Alfred Buck3, Roger M Nitsch1, Peter CM van Zijl2, Christoph Hock1, and Paul G Unschuld1

1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland, 2F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, MD, United States, 3Department of Nuclear Medicine, University of Zurich, Switzerland

To extend findings on the use of QSM in Alzheimer’s Disease and possible direct interactions with Amyloid-β, this study is investigating a growing sample of elderly subjects using simultaneous assessment of Amyloid-PET for Aβ-load and QSM for estimation of iron load (indicated by susceptibility) using a combined PET-MRI instrument.

Our preliminary data suggests a significant correlation between susceptibility and Aβ in subjects with high brain Aβ load or clinically diagnosed Mild Cognitive Impairment, in several cortical and sub-cortical regions. The sample is expected to grow considerably in the upcoming months.

This abstract and the presentation materials are available to members only; a login is required.

Join Here