Abstract #1211

Quantitative Susceptibility Mapping (QSM) Overcomes R2* Confounding Factors for Measuring Liver Iron

Jianqi Li¹, Qi Song², Tian Liu³, Zhuwei Zhang⁴, Martin R Prince³, Kelly Gillen³, Xu Yan⁵, Shu Cheng⁶, Ting Hua⁴, Xiance Zhao¹, Miao Zhang¹, Yu Zhao¹, Gaiying Li¹, Guangyu Tang⁴, Guang Yang¹, Gary M Brittenham⁷, and Yi Wang^1,3,8

¹Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, People's Republic of China, ²Department of Radiology, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, ³Department of Radiology, Weill Medical College of Cornell University, New York, New York, United States, ⁴Department of Radiology, Shanghai Tenth People's Hospital Affiliated to Tongji University, School of Medicine, Shanghai, People's Republic of China, ⁵MR Collaboration NE Asia, Siemens Healthcare, Shanghai, People's Republic of China, ⁶Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, ⁷Department of Pediatrics, Columbia University, New York, New York, United States, ⁸Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States

A major challenge in the R2 and R2* methods for mapping liver iron content is that they can be confounded by fat, fibrosis and other changes in cellularity that are known to contribute to R2 and R2*. In this paper, the fat contribution to liver susceptibility was estimated and removed from the measured liver susceptibility with validation on a gadolinium-fat-water phantom. In patients, fat-corrected QSM was found to be insensitive to liver diseases including fat and tumor, which had extensive effects on R2*. Therefore, QSM can overcome confounding factors in R2* for mapping liver iron content.

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