Abstract #1230

Measurement of Brown Adipose Tissue Activity in Response to Thermal Challenges Using Dixon MRI

Jie Deng^1,2, Nicholas Rubert¹, Lisa M Neff³, Richard Shore^1,2, Christina Sammet^1,2, and Jonathan Samet^1,2

¹Medical Imaging, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, United States, ²Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ³Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

Brown adipose tissue (BAT) is the primary site of adaptive thermogenesis, which may play a potential role in the pathogenesis and treatment of obesity, and related metabolic disorders. The purpose of this study is to use Dixon MRI to measure BAT tissue properties under pre-cold, post-cold individualized non-shivering thermogenesis, and re-warm-up conditions, in order to evaluate BAT activity among normal-weight, over-weight and obese subjects.

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