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Abstract #1255

GABA-edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

Peter O Magnusson1, Vincent O Boer1, Anouk Marsman1, Henrik Lundell1, Lars G Hanson1,2, and Esben T Petersen1,2

1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark, 2Center for Magnetic Resonance, DTU Elektro, Technical University of Denmark, Lyngby, Denmark

Magnetic resonance spectroscopy (MRS) benefits from increased magnetic field-strength in terms of increased sensitivity and spectral separation and human cerebral concentrations of neurotransmitters have been measured with improved precision at 7T. We utilize the high sensitivity at 7T for accelerated magnetic resonance spectroscopic imaging (MRSI) of the gamma-aminobutyric acid (GABA) inhibitory neurotransmitter in the human brain at 7T using spectral editing (MEGA) and a semi-localized by adiabatic selective refocusing (sLASER) with echo-planar readout (EPSI). The proposed method is shown to allow for localized GABA detection and demonstrate potential for efficient imaging of GABA.

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