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Abstract #1261

High-Resolution 4D Real-Time Phase-Contrast Flow MRI with Sparse Sampling

Aiqi Sun1, Bo Zhao2, Rui Li1, and Chun Yuan1,3

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China, 2Martinos Center for Biomedical Imaging, Harvard Medical School, Chalestown, MA, United States, 3Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States

This work presents a model-based imaging method, which integrates low-rank modeling, sparse modeling with parallel imaging, to enable 4D real-time phase-contrast flow MRI without ECG gating and respiration control. The proposed method achieves real-time imaging at a spatial resolution of 2.4 mm, temporal resolution of 35 ms, with three directional flow encodings, and well resolves beat-by-beat flow variations, which cannot be achieved by the conventional cine-based method. The proposed has been evaluated by in vivo data with multiple healthy subjects and one arrhythmic patient. For the first time, we demonstrate the feasibility of real-time 4D PC flow MRI.

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