Abstract #1306

Impact of image registration on renal T1 mapping in children with chronic kidney disease

Fabio Nery¹, Enrico De Vita^2,3, Chris A. Clark¹, Isky Gordon¹, and David L. Thomas³

¹UCL Great Ormond Street Institute of Child Health, Developmental Imaging and Biophysics Section, London, United Kingdom, ²National Hospital for Neurology and Neurosurgery, Lysholm Department of Neuroradiology;, ³UCL Institute of Neurology, Department of Brain Repair and Rehabilitation

Renal longitudinal relaxation time (T₁) is an established indicator of pathophysiological tissue status. We have applied image registration techniques to correct for motion during saturation recovery (SR) acquisitions with multiple recovery times used for T₁ mapping in kidneys of paediatric patients. All registration techniques were successful in improving the intra and inter-session repeatability of the T₁ estimates, as well as the quality of the underlying saturation recovery fits on a challenging patient population, as assessed by intra- and inter-scan repeatability and analysis of the root mean squared error of the SR fits.

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