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Abstract #1333

Simultaneous Estimation of ADC, T2-relaxation, Perfusion and 11C-acetate PET Uptake in Prostate Cancer

Mikael Skorpil1,2, Patrik Brynolfsson1, Axel Hartwig3, and Mathias Engström4

1Department of Radiation Sciences, Umeå University, Umeå, Sweden, 2Department of Radiology, Uppsala, Sweden, 3Healthcare Systems, GE Healthcare, Stockholm, Sweden, 4Applied Science Laboratory, GE Healthcare, Uppsala, Sweden

Multiparametric MRI is the standard to evaluate suspected prostate cancer. T2-weighted and DWI are essential, while DCE is less crucial. We here demonstrate that simultaneous quantification of ADC, T2-relaxation and perfusion fraction f, which was calculated from non-IVIM low b-value data, is feasible in combination with 11C-acetate PET/MR imaging. ADC and T2-values differed significantly between healthy tissue and cancer, while f was more inconsistent. An important benefit of simultaneous acquisition is the lack of image mismatch between T2-maps and DWI. This enables more objective tumor grading, decreased inter-rater variability and using mathematical/statistical approaches or computer-aided detection to estimate cancer probability.

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